rs10892759

A SNP in the SORL1 gene on chromosome 11. Its most notable genotype is A;A: reduced risk for Alzheimers?

Gene
SORL1
Location
Chr 11121,593,379 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodreduced risk for Alzheimers?Minor · 1.036% of people
  2. A;GNot ratednormalTypical · 0.045% of people
  3. G;GNot ratednormalTypical · 0.020% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 36% A;G 45% G;G 20%
  • European ancestry (Utah)A;A 13% A;G 42% G;G 46%
  • Han Chinese (Beijing)A;A 42% A;G 42% G;G 16%
  • Japanese (Tokyo)A;A 41% A;G 44% G;G 15%
  • Yoruba (Nigeria)A;A 43% A;G 43% G;G 14%
  • African ancestry (Southwest US)A;A 37% A;G 47% G;G 16%
  • Chinese (Denver)A;A 40% A;G 49% G;G 11%
  • Gujarati IndianA;A 44% A;G 45% G;G 12%
  • Luhya (Kenya)A;A 49% A;G 43% G;G 8%
  • Mexican ancestry (Los Angeles)A;A 31% A;G 48% G;G 21%
  • Maasai (Kenya)A;A 40% A;G 48% G;G 12%
  • TuscanA;A 12% A;G 40% G;G 48%

Other SORL1 SNPs

All SORL1 SNPs

Notes

From SNPedia

Notes

A;A

A single paper in 2007 found a link to reduced (0.83x) risk for Alzheimers.

Source and license

Adapted from rs10892759 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.