rs10893081
A SNP in the ZNF202 gene on chromosome 11. Its most notable genotype is C;C: 2x increased risk for severe atherosclerosis; 1.2x increased risk for ischemic heart disease
- Gene
- ZNF202
- Location
- Chr 11123,742,322 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 36%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableNot rated2x increased risk for severe atherosclerosis; 1.2x increased risk for ischemic heart disease
- C;TNot ratednormal
- T;TNot ratednormal
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 120 words
rs10893081 is a SNP in the promoter region upstream of the ZNF202 gene. This SNP is also known as -660A>G SNP of this gene (note orientation as discussed often varies from the orientation in dbSNP). Based on (1) a cross-sectional study of 5,355 Danish individuals with regard to severe atherosclerosis, (2) 10,431 Danish individuals with regard to ischemic heart disease (IHD), and (3) verification in 2 independent case-control studies including, respectively, 942 and 1,549 cases with IHD and 8,998 controls, rs10893081 was associated with risk. Specifically, rs10893081(C;C) yielded an odds ratio for severe atherosclerosis of 2.01 (CI: 1.34 to 3.01), and prospectively, a hazard ratio for IHD of 1.21 (CI: 1.02 to 1.43).
Source and license
Adapted from rs10893081 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.