rs10980705
A SNP in the LPAR1 gene on chromosome 9. Its most notable genotype is T;T: 3.7x increased risk for knee osteoarthritis
- Gene
- LPAR1
- Location
- Chr 9111,040,905 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 19%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodNormal risk for knee osteoarthritis
- C;TBad2.3x increased risk for knee osteoarthritis
- T;TMost notableBad3.7x increased risk for knee osteoarthritis
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 71% C;T 25% T;T 4%
- European ancestry (Utah)C;C 54% C;T 39% T;T 7%
- Han Chinese (Beijing)C;C 63% C;T 33% T;T 4%
- Japanese (Tokyo)C;C 62% C;T 34% T;T 5%
- Yoruba (Nigeria)C;C 99% C;T <1% T;T 0%
- African ancestry (Southwest US)C;C 88% C;T 12% T;T 0%
- Chinese (Denver)C;C 59% C;T 38% T;T 4%
- Gujarati IndianC;C 66% C;T 31% T;T 3%
- Luhya (Kenya)C;C 97% C;T 3% T;T 0%
- Mexican ancestry (Los Angeles)C;C 41% C;T 45% T;T 14%
- Maasai (Kenya)C;C 94% C;T 6% T;T 0%
- TuscanC;C 64% C;T 30% T;T 6%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 160 words
rs10980705, also known as -2820G/A, is a SNP upstream of the lysophosphatidic acid receptor 1 LPAR1 gene. In a study of 2 Japanese populations of patients with knee osteoarthritis (OA), the rs10980705(T) allele (in dbSNP orientation) was associated with increased risk in two Japanese populations, with an odds ratio of 2.3 (CI: 1.6-3.3, p=2.6x10 -5 ). The association appears to hold only for the homozygous (T;T) genotype, and the authors state they believe this variant may be the "disease-causing SNP". However, 2% of individuals without knee OA are (T;T) homozygotes, and, over 50% of all patients with knee OA are (C;C) homozygotes. In a study of five collections of samples, and a meta-analysis combining them all, no particularly significant association was seen for rs10980705 with either knee OA or hip OA. These authors conclude it's either a weak effect (and more people need to be studied), or perhaps it's a phenomena more relevant to Asians than to Europeans.
Source and license
Adapted from rs10980705 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.