rs10984447

A SNP in the DBC1 gene on chromosome 9. Its most notable genotype is A;A: >1.17x increased risk for multiple sclerosis

Gene
DBC1
Location
Chr 9119,222,275 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad>1.17x increased risk for multiple sclerosisWorth knowing · 2.076% of people
  2. A;GBad1.17x increased risk for multiple sclerosisWorth knowing · 2.021% of people
  3. G;GGoodNormal risk for multiple sclerosisMinor · 1.03% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 76% A;G 21% G;G 3%
  • European ancestry (Utah)A;A 52% A;G 40% G;G 8%
  • Han Chinese (Beijing)A;A 83% A;G 16% G;G <1%
  • Japanese (Tokyo)A;A 73% A;G 25% G;G 3%
  • Yoruba (Nigeria)A;A 89% A;G 11% G;G 0%
  • African ancestry (Southwest US)A;A 81% A;G 18% G;G 2%
  • Chinese (Denver)A;A 81% A;G 18% G;G <1%
  • Gujarati IndianA;A 60% A;G 35% G;G 5%
  • Luhya (Kenya)A;A 93% A;G 6% G;G <1%
  • Mexican ancestry (Los Angeles)A;A 59% A;G 28% G;G 14%
  • Maasai (Kenya)A;A 94% A;G 6% G;G 0%
  • TuscanA;A 68% A;G 29% G;G 3%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs10984447 has been reported in a large study to be associated with multiple sclerosis. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with this allele is 1.17 (CI 1.09-1.25).

Source and license

Adapted from rs10984447 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.