rs10989591

A SNP in the GRIN3A gene on chromosome 9. Its most notable genotype is C;C: common

Gene
GRIN3A
Location
Chr 9101,686,816 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommonTypical · 0.047% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 47%
  • European ancestry (Utah)C;C 50%
  • Han Chinese (Beijing)C;C 89%
  • Japanese (Tokyo)C;C 58%
  • Yoruba (Nigeria)C;C 25%
  • African ancestry (Southwest US)C;C 30%
  • Chinese (Denver)C;C 88%
  • Gujarati IndianC;C 39%
  • Luhya (Kenya)C;C 15%
  • Mexican ancestry (Los Angeles)C;C 60%
  • Maasai (Kenya)C;C 26%
  • TuscanC;C 35%

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 130 words

rs10989591, aka Val362Met or V362M, is a SNP in the N-methyl-D-aspartate 3A GRIN3A gene, which codes for the N-methyl-D-aspartate 3A subunit of the glutamate N-methyl-D-aspartate receptor. The (C) allele encodes the Val and the (T) allele encodes the Met. gs278 reflects a gene-gene interaction between this SNP and a DRD2 SNP, rs6277, in which older adults with a particular combination of genotypes at these two (independent) loci are reported to exhibit better episodic memory. Based on electromagnetic activity during selective attention (auditory oddball task with target processing) measured in 281 healthy subjects, rs10989591(T;T) individuals appeared to show better prefrontal information processing (based on higher frontal P300 amplitudes), presumably reflecting higher NMDA receptor efficacy.

Source and license

Adapted from rs10989591 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.