rs10993994

A SNP in the MSMB gene on chromosome 10. Its most notable genotype is T;T: increased prostate cancer risk (odds ratio 1.6)

Gene
MSMB
Location
Chr 1046,046,326 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNo summary available.Typical · 0.025% of people
  2. C;TBadincreased prostate cancer risk (odds ratio 1.2)Minor · 1.542% of people
  3. T;TMost notableBadincreased prostate cancer risk (odds ratio 1.6)Worth knowing · 2.033% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 25% C;T 42% T;T 33%
  • European ancestry (Utah)C;C 44% C;T 43% T;T 12%
  • Han Chinese (Beijing)C;C 27% C;T 49% T;T 24%
  • Japanese (Tokyo)C;C 39% C;T 46% T;T 15%
  • Yoruba (Nigeria)C;C 11% C;T 37% T;T 52%
  • African ancestry (Southwest US)C;C 23% C;T 37% T;T 40%
  • Chinese (Denver)C;C 28% C;T 40% T;T 32%
  • Gujarati IndianC;C 19% C;T 43% T;T 39%
  • Luhya (Kenya)C;C 8% C;T 34% T;T 58%
  • Mexican ancestry (Los Angeles)C;C 45% C;T 47% T;T 9%
  • Maasai (Kenya)C;C 4% C;T 36% T;T 60%
  • TuscanC;C 33% C;T 49% T;T 18%

Conditions, medicines and genes

Other MSMB SNPs

All MSMB SNPs

Notes

From SNPedia

Notes

rs10993994 linked to prostate cancer cancer-genetics these snps influence genetic risk for prostate cancer *the haplotype rs6983267 rs1016343 rs4242384 *rs7501939 *rs1859962 *rs2660753 *rs9364554 *rs6465657 *rs10993994 *rs7931342 *rs2735839 *rs5945619 {{PMID Auto |PMID=20696662 |Title=Polymorphisms at the Microseminoprotein-{beta} Locus Associated with Physiologic Variation in {beta}-Microseminoprotein and Prostate-Specific Antigen Levels |OA=1 }}

C;T

Compared to the (C;C) genotype for this SNP, (C;T) genotypes are estimated to be at 1.2x increased risk for prostate cancer.

T;T

Compared to the (C;C) genotype for this SNP, (T;T) genotypes are estimated to be at 1.6x increased risk for prostate cancer.

Source and license

Adapted from rs10993994 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.