rs10994336

A SNP in the ANK3 gene on chromosome 10. Its most notable genotype is C;T: 1.45x increased odds of developing bipolar disorder

Gene
ANK3
Location
Chr 1060,420,054 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
13%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon on affy axiom dataTypical · 0.075% of people
  2. C;TMost notableBad1.45x increased odds of developing bipolar disorderWorth knowing · 2.020% of people
  3. T;TBad2.9x increased odds of developing bipolar disorderWorth knowing · 2.05% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 75% C;T 20% T;T 5%
  • European ancestry (Utah)C;C 86% C;T 14% T;T 0%
  • Han Chinese (Beijing)C;C 67% C;T 27% T;T 7%
  • Japanese (Tokyo)C;C 47% C;T 40% T;T 14%
  • Yoruba (Nigeria)C;C 100% C;T 0% T;T 0%

Other ANK3 SNPs

All ANK3 SNPs

Notes

From SNPedia

Notes

23andMe blog rs10994336 or (rs4948418) Each T at this SNP increased the odds of developing bipolar disorder by 1.45 times compared to the CC genotype. This is one of the SNPs reported by NutraHacker.

Source and license

Adapted from rs10994336 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.