rs11031006

A SNP in the LOC105376607 gene on chromosome 11. Its most notable genotype is A;A: slightly lower odds of giving birth to fraternal twins

Gene
LOC105376607
Location
Chr 1130,204,981 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedslightly lower odds of giving birth to fraternal twinsMinor · 1.5<1% of people
  2. A;GNot ratedslightly lower odds of giving birth to fraternal twinsMinor · 1.512% of people
  3. G;GNot ratedMost common genotype; slightly higher odds of giving birth to fraternal twinsMinor · 1.588% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A <1% A;G 12% G;G 88%
  • European ancestry (Utah)A;A <1% A;G 20% G;G 79%
  • Han Chinese (Beijing)A;A 0% A;G 6% G;G 94%
  • Japanese (Tokyo)A;A 0% A;G 5% G;G 95%
  • Yoruba (Nigeria)A;A 0% A;G 9% G;G 91%
  • African ancestry (Southwest US)A;A 0% A;G 9% G;G 91%
  • Chinese (Denver)A;A 0% A;G 6% G;G 94%
  • Gujarati IndianA;A 0% A;G 16% G;G 84%
  • Luhya (Kenya)A;A 0% A;G <1% G;G 99%
  • Mexican ancestry (Los Angeles)A;A 2% A;G 18% G;G 81%
  • Maasai (Kenya)A;A <1% A;G 15% G;G 85%
  • TuscanA;A 1% A;G 24% G;G 75%

Notes

From SNPedia

Notes

A meta-analysis found that the most common allele for this SNP, rs11031006(G), is actually associated with a slightly higher likelihood of giving birth to fraternal (dizygotic) twins (odds ratio 1.41, CI:1.29–1.53, p= 1.54 × 10e−9) compared to carriers of the (A) allele. A subsequent replication study of Icelanders yielded lower odds (1.14, CI:1.06–1.22,p=3 × 10e−3).

A;A

see discussion at rs11031006

A;G

see discussion at rs11031006

G;G

see discussion at rs11031006

Source and license

Adapted from rs11031006 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.