rs11045585

A SNP in the SLCO1B3 gene on chromosome 12. Its most notable genotype is A;A: 24% chance (lower than average) of docetaxel-induced leukopenia/neutropenia

Gene
SLCO1B3
Location
Chr 1220,892,760 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGood24% chance (lower than average) of docetaxel-induced leukopenia/neutropeniaWorth knowing · 2.071% of people
  2. A;GBad63% chance (higher than average) of docetaxel-induced leukopenia/neutropeniaWorth knowing · 2.027% of people
  3. G;GNot rated(no data; implied high chance of docetaxel-induced leukopenia/neutropenia)Typical · 0.02% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 71% A;G 27% G;G 2%
  • European ancestry (Utah)A;A 72% A;G 26% G;G 2%
  • Han Chinese (Beijing)A;A 64% A;G 34% G;G 2%
  • Japanese (Tokyo)A;A 74% A;G 22% G;G 4%
  • Yoruba (Nigeria)A;A 62% A;G 35% G;G 3%
  • African ancestry (Southwest US)A;A 70% A;G 25% G;G 5%
  • Chinese (Denver)A;A 72% A;G 28% G;G <1%
  • Gujarati IndianA;A 91% A;G 9% G;G 0%
  • Luhya (Kenya)A;A 56% A;G 37% G;G 6%
  • Mexican ancestry (Los Angeles)A;A 79% A;G 21% G;G 0%
  • Maasai (Kenya)A;A 63% A;G 35% G;G 2%
  • TuscanA;A 79% A;G 21% G;G 0%

Conditions, medicines and genes

Other SLCO1B3 SNPs

All SLCO1B3 SNPs

Notes

From SNPedia

Show notes, about 150 words

rs12762549 and rs11045585 can be used to predict whether docetaxel will induce leukopenia/neutropenia, according to a study of ~100 Japanese patients. When patients were classified into three groups by the scoring system based on the genotypes of these two SNPs, patients with a score of 1 or 2 were shown to have a significantly higher risk of docetaxel-induced leukopenia/neutropenia as compared to those with a score of 0 (P = 0.0000057; odds ratio [OR], 7.00; 95% CI [confidence interval], 2.95-16.59). This prediction system correctly classified 69.2% of severe leukopenia/neutropenia and 75.7% of non-leukopenia/neutropenia into the respective categories. [Effect percentages provided in table are raw population fractions taken from the referenced study based on rs11045585 only. Total population size = 113. Breakdown: leukopenia/neutropenia: AA=20 AG=19; non-leukopenia/neutropenia: AA=63 AG=11]

Source and license

Adapted from rs11045585 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.