rs111033565

A SNP in the PRSS1 gene on chromosome 7. Its most notable genotype is A;G: Hereditary pancreatitis

Gene: PRSS1
Location: Chr 7142,751,938 (GRCh38)
Highest magnitude: 4.4Very important
Tested on: AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Hereditary pancreatitisCondition

Other PRSS1 SNPs

All PRSS1 SNPs

Notes

From SNPedia

Show notes, about 130 words

aka c.365G>A, p.Arg122His, and R122H ; 23andMe name: i5005351 The rs111033565(A) mutant allele is reported to be the most common mutation found in early-onset (pediatric) acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). Monoclonal antibodies which identify carbohydrate-defined MHC class I epitopes. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Heterogeneity in hereditary pancreatitis. Estimation of the prevalence and incidence of chronic pancreatitis and its complications. Role of genetic disorders in acute recurrent pancreatitis. Prevalence of pancreatic diabetes in patients carrying mutations or polymorphisms of the PRSS1 gene in the Han population.

A;G

see rs111033565, PRSS1 and hereditary pancreatitis

Source and license

Adapted from rs111033565 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.