rs11110912

A SNP in the LOC105369937 gene on chromosome 12. Its most notable genotype is C;G: Maybe some quite minor increase in high blood pressure risk; data not replicated though

Gene
LOC105369937
Location
Chr 12101,648,435 (GRCh38)
Highest magnitude
0.1Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.077% of people
  2. C;GMost notableBadMaybe some quite minor increase in high blood pressure risk; data not replicated thoughTypical · 0.121% of people
  3. G;GBadMaybe some quite minor increase in high blood pressure risk; data not replicated thoughTypical · 0.12% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 77% C;G 21% G;G 2%
  • European ancestry (Utah)C;C 61% C;G 35% G;G 4%
  • Han Chinese (Beijing)C;C 81% C;G 19% G;G 0%
  • Japanese (Tokyo)C;C 80% C;G 20% G;G 0%
  • Yoruba (Nigeria)C;C 91% C;G 9% G;G 0%
  • African ancestry (Southwest US)C;C 86% C;G 14% G;G 0%
  • Chinese (Denver)C;C 81% C;G 19% G;G 0%
  • Gujarati IndianC;C 66% C;G 29% G;G 5%
  • Luhya (Kenya)C;C 87% C;G 13% G;G 0%
  • Mexican ancestry (Los Angeles)C;C 85% C;G 16% G;G 0%
  • Maasai (Kenya)C;C 64% C;G 32% G;G 5%
  • TuscanC;C 70% C;G 23% G;G 7%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs11110912 was reported in a 2007 study to be associated with high blood pressure. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.33 (CI 1.18-1.51), and for homozygotes, 1.34 (CI 0.96-1.86). Note: rs11110912 did not replicate in this 2008 study.

Source and license

Adapted from rs11110912 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.