rs11212617

A SNP in the C11orf65 gene on chromosome 11. Its most notable genotype is A;C: Somewhat increased likelihood of treatment success with metformin

Gene
C11orf65
Location
Chr 11108,412,434 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormal response to MetforminTypical · 0.022% of people
  2. A;CMost notableGoodSomewhat increased likelihood of treatment success with metforminMinor · 1.539% of people
  3. C;CGoodSomewhat increased likelihood of treatment success with metforminMinor · 1.539% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 22% A;C 39% C;C 39%
  • European ancestry (Utah)A;A 27% A;C 54% C;C 20%
  • Han Chinese (Beijing)A;A 16% A;C 39% C;C 45%
  • Japanese (Tokyo)A;A 20% A;C 41% C;C 40%
  • Yoruba (Nigeria)A;A 2% A;C 32% C;C 66%
  • African ancestry (Southwest US)A;A 18% A;C 37% C;C 46%
  • Chinese (Denver)A;A 17% A;C 50% C;C 34%
  • Gujarati IndianA;A 47% A;C 39% C;C 15%
  • Luhya (Kenya)A;A 4% A;C 30% C;C 67%
  • Mexican ancestry (Los Angeles)A;A 36% A;C 41% C;C 22%
  • Maasai (Kenya)A;A 8% A;C 33% C;C 59%
  • TuscanA;A 54% A;C 33% C;C 13%

Conditions, medicines and genes

Other C11orf65 SNPs

All C11orf65 SNPs

Notes

From SNPedia

Notes

Influences Metformin response

Source and license

Adapted from rs11212617 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.