rs1128535

A SNP in the TRAIP gene on chromosome 3. Its most notable genotype is C;C: reduced risk (0.77x) for Crohn's disease

Gene
TRAIP
Location
Chr 349,828,959 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe
Minor allele frequency
39%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TBadnormalTypical · 0.59% of people
  2. C;TGood0.77x risk for Crohn's diseaseMinor · 1.838% of people
  3. C;CMost notableGoodreduced risk (0.77x) for Crohn's diseaseWorth knowing · 2.053% of people

SNPedia records rs1128535 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 3 HapMap populations.

  • AverageT;T 9% C;T 38% C;C 53%
  • European ancestry (Utah)T;T 27% C;T 56% C;C 17%
  • Han Chinese (Beijing)T;T 0% C;T 23% C;C 77%
  • Japanese (Tokyo)T;T 0% C;T 35% C;C 65%

Conditions, medicines and genes

Notes

From SNPedia

Notes

The less common allele of rs1128535, a SNP in the TRAIP gene, may have a protective effect against the development of Crohn's disease, based on a study of 469 Caucasian patients. The reported odds ratio is 0.77 (CI: 0.67-0.89, p=0.002). Note that rs1128535 is highly correlated (r 2 > 0.8) to nonsynonymous SNPs in the nearby MST1R gene, rs2230590 and rs1062633, also known as Arg523Gln and Gly1335Arg, respectively.

Source and license

Adapted from rs1128535 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.