rs1131532

A SNP in the TNFSF10 gene on chromosome 3. Its most notable genotype is G;G: normal

Gene
TNFSF10
Location
Chr 3172,506,513 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
34%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormalTypical · 0.044% of people
  2. A;GNot ratednormalTypical · 0.043% of people
  3. A;ANot rated3-6x higher odds of worse outcomes in breast cancer patientsTypical · 0.013% of people

SNPedia records rs1131532 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 44% A;G 43% A;A 13%
  • European ancestry (Utah)G;G 44% A;G 47% A;A 10%
  • Han Chinese (Beijing)G;G 31% A;G 49% A;A 20%
  • Japanese (Tokyo)G;G 43% A;G 39% A;A 18%
  • Yoruba (Nigeria)G;G 59% A;G 38% A;A 3%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1131532 is a SNP in the tumor necrosis factor superfamily member 10 TNFSF10 gene. A study of 240 patients with early invasive ductal breast cancer followed for a median of 53 months concluded that rs1131532(T;T) individuals had lower odds of being disease-free or distant-disease free, and for overall survival (hazard ratio 3.304, 4.757, and 6.459; p = 0.002, 0.001, and 0.009, respectively).

Source and license

Adapted from rs1131532 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.