rs11362

A SNP in the DEFB1 gene on chromosome 8. Its most notable genotype is C;T.

Gene
DEFB1
Location
Chr 86,877,877 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
40%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;TMost notableNot ratedNo summary available.Minor · 1.048% of people

SNPedia records rs11362 on the minus strand: (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;T 48%
  • European ancestry (Utah)C;T 45%
  • Han Chinese (Beijing)C;T 48%
  • Japanese (Tokyo)C;T 53%
  • Yoruba (Nigeria)C;T 36%
  • African ancestry (Southwest US)C;T 51%
  • Chinese (Denver)C;T 49%
  • Gujarati IndianC;T 54%
  • Luhya (Kenya)C;T 43%
  • Mexican ancestry (Los Angeles)C;T 50%
  • Maasai (Kenya)C;T 46%
  • TuscanC;T 48%

Conditions, medicines and genes

Other DEFB1 SNPs

All DEFB1 SNPs

Notes

From SNPedia

Notes

Heterozygotes for SNP rs11362, located in the DEFB1 gene, are reported to be at increased risk for colonic Crohn's disease - but not the ileal or ileocolonic forms of the disease - based on a study of 190 Caucasians. The odds ratio is 2.393 (CI: 1.18-4.87, p=0.02). G-20A rs11362(A;G) 2.4x risk colonic and ileocolonic Crohn's disease but no association was detected for the ileal localization

Source and license

Adapted from rs11362 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.