rs1136410

A SNP in the PARP1 gene on chromosome 1. Its most notable genotype is G;G: 0.80x reduced risk for glioblastoma as well a 84% in CAD risk

Gene
PARP1
Location
Chr 1226,367,601 (GRCh38)
Highest magnitude
2.4Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
24%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGood0.80x reduced risk for glioblastoma as well a 84% in CAD riskWorth knowing · 2.48% of people
  2. A;GGood0.80x reduced risk for glioblastomaWorth knowing · 2.026% of people
  3. A;ANot ratednormalTypical · 0.066% of people

SNPedia records rs1136410 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 8% A;G 26% A;A 66%
  • European ancestry (Utah)G;G 4% A;G 23% A;A 74%
  • Han Chinese (Beijing)G;G 17% A;G 53% A;A 31%
  • Japanese (Tokyo)G;G 26% A;G 41% A;A 34%
  • Yoruba (Nigeria)G;G 0% A;G 5% A;A 95%
  • African ancestry (Southwest US)G;G 0% A;G 16% A;A 84%
  • Chinese (Denver)G;G 19% A;G 53% A;A 28%
  • Gujarati IndianG;G 4% A;G 15% A;A 81%
  • Luhya (Kenya)G;G 0% A;G 13% A;A 87%
  • Mexican ancestry (Los Angeles)G;G 21% A;G 36% A;A 43%
  • Maasai (Kenya)G;G 1% A;G 9% A;A 90%
  • TuscanG;G 1% A;G 19% A;A 80%

Other PARP1 SNPs

All PARP1 SNPs

Notes

From SNPedia

Show notes, about 230 words

rs1136410, also known as V762A, is a SNP in the PARP1 Poly(ADP-ribose) polymerase-1 gene. The rs1136410(C) allele encodes the less common A (alanine) amino acid at this codon. A study of 1,000 glioblastoma multiforme cases and 2,000 controls in the US concluded that the PARP1 gene rs1136410(C) allele was associated with a 20% reduction in risk for glioblastoma multiforme (odds ratio 0.80, CI: 0.67-0.95). A meta-analysis of 21 studies with 12,027 cancer patients found no significant association overall between rs1136410 and cancer risk, however, in the stratified analyses, rs1136410(C) was associated with an increased risk of cancer among Asian populations (CT + CC vs. TT: odds ratio 1.11, CI: 1.01-1.23, p(heterogeneity) = 0.210), but a decreased risk of cancer (CT + CC vs. TT: odds ratio 0.89, CI: 0.80-1.00, p(heterogeneity) = 0.004) among Caucasian populations, especially for glioma risk (odds ratio 0.79, CI: 0.69-0.90, p(heterogeneity) = 0.800). A study of 2803 CAD patients and 2840 controls in a Chinese Han population has found a significantly reduced risk of 84% for the rs1136410 GG polymorphism, but without smoking habit, type 2 diabetes mellitus, and hyperlipidemia. This recessive model protection is highly probable explained due to a decrease of PARP activity.

G;G

This recessive module is highly protective against CAD in a Han Chinese population

References

Source and license

Adapted from rs1136410 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.