rs11385942
A SNP. Its most notable genotype is A;A: Among COVID-19 patients, higher respiratory failure susceptibility
- Gene
- None listed
- Highest magnitude
- 3.0Important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Goodcommon/normal
- -;ABadAmong COVID-19 patients, more susceptible to respiratory failure
- A;AMost notableBadAmong COVID-19 patients, higher respiratory failure susceptibility
On SNPedia: (-;-), (-;A), (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Notes
From SNPedia
Show notes, about 200 words
Located in an intronic region of chromosome 3, the minor rs11385942(A) allele yielded the strongest association signal across the genome for respiratory failure among COVID-19 patients (OR 1.77, CI:1.5-2.1,p=1.15×10e−10), and also for needing mechanical ventilation. The 19 patients who were homozygous for the minor allele, i.e. had genotype rs11385942(A;A), were also younger than the 1,591 patients who were heterozygous or homozygous for the nonrisk allele (median age, 59 years vs. 66 years; p=0.005). Note that rs11385942 is not present on the DNA chips used by the major direct-to-consumer genotyping companies such as 23andMe, Ancestry and MyHeritage. In Caucasians, a SNP present on most MyHeritage and Ancestry chips, rs10490770, is a very good proxy for rs11385942 (and it is also present on older versions of the 23andMe chip). The minor allele of rs10490770(C) corresponds most of the time (r2 >0.99 in Caucasians) to the minor rs11385942(A) allele based on data available in ensembl. There is no equivalent linkage in those of African descent; and the correlation is lower in Hispanic populations (r2 ~0.8-0.9).
-;A
see article referenced via main rs-page
A;A
see article referenced via main rs-page
Source and license
Adapted from rs11385942 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.