rs1144393

A SNP in the MMP1 gene on chromosome 11. Its most notable genotype is C;C: 1.3x risk of chronic kidney disease in Japanese

Gene
MMP1
Location
Chr 11102,798,678 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.3x risk of chronic kidney disease in JapaneseTypical · 0.03% of people
  2. C;TBad1.3x risk of chronic kidney diseaseTypical · 0.028% of people
  3. T;TGoodnormal risk of chronic kidney diseaseTypical · 0.069% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 3% C;T 28% T;T 69%
  • European ancestry (Utah)C;C 12% C;T 49% T;T 39%
  • Han Chinese (Beijing)C;C 0% C;T 20% T;T 80%
  • Japanese (Tokyo)C;C 3% C;T 14% T;T 83%
  • Yoruba (Nigeria)C;C 1% C;T 29% T;T 70%
  • African ancestry (Southwest US)C;C 4% C;T 30% T;T 66%
  • Chinese (Denver)C;C <1% C;T 16% T;T 84%
  • Gujarati IndianC;C 1% C;T 30% T;T 69%
  • Luhya (Kenya)C;C 0% C;T 18% T;T 82%
  • Mexican ancestry (Los Angeles)C;C 4% C;T 28% T;T 68%
  • Maasai (Kenya)C;C 2% C;T 26% T;T 72%
  • TuscanC;C 7% C;T 50% T;T 44%

Other MMP1 SNPs

All MMP1 SNPs

Notes

From SNPedia

Notes

Association of genetic variants with chronic kidney disease in Japanese individuals.

Source and license

Adapted from rs1144393 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.