rs1148259

A SNP in the ANKRD30A gene on chromosome 10. Its most notable genotype is C;C: lowest sphingomyelin ratios

Gene
ANKRD30A
Location
Chr 1037,219,522 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
49%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedlowest sphingomyelin ratiosTypical · 0.029% of people
  2. A;CNot ratedintermediate sphingomyelin ratiosTypical · 0.046% of people
  3. A;ANot ratedhighest sphingomyelin ratiosTypical · 0.025% of people

SNPedia records rs1148259 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 29% A;C 46% A;A 25%
  • European ancestry (Utah)C;C 14% A;C 45% A;A 41%
  • Han Chinese (Beijing)C;C 47% A;C 44% A;A 9%
  • Japanese (Tokyo)C;C 56% A;C 38% A;A 6%
  • Yoruba (Nigeria)C;C 13% A;C 46% A;A 42%
  • African ancestry (Southwest US)C;C 23% A;C 41% A;A 36%
  • Chinese (Denver)C;C 39% A;C 49% A;A 13%
  • Gujarati IndianC;C 51% A;C 43% A;A 7%
  • Luhya (Kenya)C;C 15% A;C 47% A;A 38%
  • Mexican ancestry (Los Angeles)C;C 22% A;C 53% A;A 24%
  • Maasai (Kenya)C;C 18% A;C 51% A;A 31%
  • TuscanC;C 21% A;C 50% A;A 29%

Notes

From SNPedia

Notes

rs1148259 is a SNP located in the ankyrin repeat domain 30A ANKRD30A gene. A study of metabolite concentrations in the blood of 284 adult males from Southern Germany determined that several SNPs were associated either directly with a metabolite range or with a ratio of metabolites. The rarer rs1148259(T) allele was associated with increased sphingomyelin ratios. 296px|thumb|left|

Source and license

Adapted from rs1148259 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.