rs11523871

A SNP in the DMBT1 gene on chromosome 10. Its most notable genotype is A;C: 1.6x increased breast cancer risk for women over 60

Gene
DMBT1
Location
Chr 10122,570,194 (GRCh38)
Highest magnitude
1.6Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormalTypical · 0.054% of people
  2. A;CMost notableBad1.6x increased breast cancer risk for women over 60Minor · 1.641% of people
  3. C;CBad>1.6x increased breast cancer risk for women over 60Minor · 1.65% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 54% A;C 41% C;C 5%
  • European ancestry (Utah)A;A 43% A;C 49% C;C 8%
  • Han Chinese (Beijing)A;A 66% A;C 32% C;C 2%
  • Japanese (Tokyo)A;A 67% A;C 33% C;C 0%
  • Yoruba (Nigeria)A;A 41% A;C 51% C;C 8%

Conditions, medicines and genes

Other DMBT1 SNPs

All DMBT1 SNPs

Notes

From SNPedia

Notes

rs11523871, also known as 124A>C or Thr42Pro, is a SNP in the Deleted in Malignant Brain Tumors 1 DMBT1 gene. For more information about increased breast cancer risk for this SNP, see the SNPedia entry for rs2981745, to which it is tightly linked.

Source and license

Adapted from rs11523871 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.