rs1154510

A SNP in the LOC105370035 gene on chromosome 12. Its most notable genotype is C;T: likely to be benign

Gene
LOC105370035
Location
Chr 12121,857,429 (GRCh38)
Highest magnitude
0.5Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
13%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon in clinvarTypical · 0.02% of people
  2. C;TMost notableGoodlikely to be benignTypical · 0.521% of people
  3. G;GNot ratedNo summary available.Typical · 0.00% of people
  4. C;CGoodcommon in complete genomicsTypical · 0.077% of people

SNPedia records rs1154510 on the minus strand: (A;A), (A;G), (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 2% C;T 21% G;G 0% C;C 77%
  • European ancestry (Utah)T;T 2% C;T 21% G;G 0% C;C 77%
  • Han Chinese (Beijing)T;T 2% C;T 24% G;G 0% C;C 74%
  • Japanese (Tokyo)T;T 3% C;T 35% G;G 0% C;C 63%
  • Yoruba (Nigeria)T;T 0% C;T 5% G;G 0% C;C 95%
  • African ancestry (Southwest US)T;T 0% C;T 12% G;G 0% C;C 88%
  • Chinese (Denver)T;T <1% C;T 16% G;G 0% C;C 84%
  • Gujarati IndianT;T 3% C;T 36% G;G 0% C;C 61%
  • Luhya (Kenya)T;T 0% C;T 14% G;G 0% C;C 86%
  • Mexican ancestry (Los Angeles)T;T 7% C;T 40% G;G 0% C;C 53%
  • Maasai (Kenya)T;T 0% C;T 6% G;G 0% C;C 94%
  • TuscanT;T 2% C;T 21% G;G 0% C;C 78%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1154510, also known as c.97G>A, p.Ala33Thr and A33T, represents a SNP in the HPD gene on chromosome 12. Although the rs1154510(A) minor allele is listed in ClinVar as pathogenic as a dominant mutation leading to hawkinsinuria, this seems quite unlikely given that the frequency of this minor allele is around 10 - 15% in most populations.

C;T

see discussion at rs1154510

Source and license

Adapted from rs1154510 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.