rs11615
A SNP in the ERCC1 gene on chromosome 19. Its most notable genotype is A;A: common in clinvar
- Gene
- ERCC1
- Location
- Chr 1945,420,395 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 36%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs11615 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 12%
- European ancestry (Utah)A;A 37%
- Han Chinese (Beijing)A;A 7%
- Japanese (Tokyo)A;A 9%
- Yoruba (Nigeria)A;A 0%
- African ancestry (Southwest US)A;A 0%
- Chinese (Denver)A;A 11%
- Gujarati IndianA;A 27%
- Luhya (Kenya)A;A 0%
- Mexican ancestry (Los Angeles)A;A 9%
- Maasai (Kenya)A;A 5%
- TuscanA;A 31%
Related
Notes
From SNPedia
Show notes, about 410 words
Gene-smoking interaction associations for the ERCC1 polymorphisms in the risk of lung cancer. Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: a meta-analysis. A distinct ERCC1 haplotype is associated with mRNA expression levels in prostate cancer patients. Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis. International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways. Effects of excision repair cross-complementation group 1 (ERCC1) single nucleotide polymorphisms on the prognosis of non-small cell lung cancer patients. Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. ERCC2, ERCC1 polymorphisms and haplotypes, cooking oil fume and lung adenocarcinoma risk in Chinese non-smoking females. Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma. ERCC1 and ERCC2 polymorphisms predict clinical outcomes of oxaliplatin-based chemotherapies in gastric and colorectal cancer: a systemic review and meta-analysis. The ERCC1 N118N polymorphism does not change cellular ERCC1 protein expression or platinum sensitivity. CYP2A6 and ERCC1 polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients. The determination of relationship between "excision repair cross-complementing group 1" (ERCC1) gene T19007C and C8092A single nucleotide polymorphisms and clinicopathological parameters in non-small cell lung cancer. HapMap-based study of a region encompassing ERCC1 and ERCC2 related to lung cancer susceptibility in a Chinese population. Neoadjuvant radiochemotherapy in adenocarcinoma of the esophagus: ERCC1 gene polymorphisms for prediction of response and prognosis. Nucleotide excision repair gene ERCC1 polymorphisms contribute to cancer susceptibility: a meta-analysis. ERCC1 polymorphisms and risk of adult glioma in a Chinese population: a hospital-based case-control study. A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population.
Source and license
Adapted from rs11615 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.