rs11622475

A SNP in the TDRD9 gene on chromosome 14. Its most notable genotype is C;C: 1.5x risk of bipolar disorder

Gene
TDRD9
Location
Chr 14104,042,739 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.5x risk of bipolar disorderTypical · 0.063% of people
  2. C;TBad1.1x risk of bipolar disorderTypical · 0.030% of people
  3. T;TNot ratednormalTypical · 0.07% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 63% C;T 30% T;T 7%
  • European ancestry (Utah)C;C 58% C;T 34% T;T 8%
  • Han Chinese (Beijing)C;C 54% C;T 39% T;T 7%
  • Japanese (Tokyo)C;C 47% C;T 44% T;T 9%
  • Yoruba (Nigeria)C;C 96% C;T 4% T;T 0%
  • African ancestry (Southwest US)C;C 81% C;T 19% T;T 0%
  • Chinese (Denver)C;C 48% C;T 49% T;T 4%
  • Gujarati IndianC;C 31% C;T 47% T;T 22%
  • Luhya (Kenya)C;C 95% C;T 5% T;T <1%
  • Mexican ancestry (Los Angeles)C;C 50% C;T 35% T;T 16%
  • Maasai (Kenya)C;C 88% C;T 12% T;T 0%
  • TuscanC;C 42% C;T 48% T;T 11%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs11622475 has been reported in a large study to be associated with bipolar disorder. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.13 (CI 0.89-1.44), and for homozygotes, 1.47 (CI 1.17-1.86).

Source and license

Adapted from rs11622475 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.