rs116446171

A SNP on chromosome 6. Its most notable genotype is C;G: Significantly increased (~20x) risk for a rare B-cell lymphoma

Gene
None listed
Location
Chr 6484,453 (GRCh38)
Highest magnitude
5.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;GMost notableBadSignificantly increased (~20x) risk for a rare B-cell lymphomaVery important · 5.0

On SNPedia: (C;C), (C;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 120 words

rs116446171 is located 679bp downstream of the 3′ untranslated region of the EXOC2 gene on chromosome 6. A 2018 study finds that the minor allele, rs116446171(G), is associated with significantly increased (~20x) risk for a rare B-cell lymphoma, Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL); the odds ratio is 21.14, CI: 14.40–31.03, p = 1.36 × 10e−54. Note that since this condition is so rare (about 2,000 new cases in total are diagnosed annually in the US), having a 20-fold higher risk for the condition compared to people not carrying this variant means carriers of this variant still have a very low overall risk of being diagnosed with this type of lymphoma.

C;G

see text on main rs-page for details

Source and license

Adapted from rs116446171 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.