rs11649743

A SNP in the LOC105371754 gene on chromosome 17. Its most notable genotype is A;A: Lower prostate cancer risk?

Gene
LOC105371754
Location
Chr 1737,714,971 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
20%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodLower prostate cancer risk?Worth knowing · 2.55% of people

On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 5%
  • European ancestry (Utah)A;A 6%
  • Han Chinese (Beijing)A;A 10%
  • Japanese (Tokyo)A;A 9%
  • Yoruba (Nigeria)A;A 0%
  • African ancestry (Southwest US)A;A 2%
  • Chinese (Denver)A;A 14%
  • Gujarati IndianA;A 1%
  • Luhya (Kenya)A;A 0%
  • Mexican ancestry (Los Angeles)A;A 2%
  • Maasai (Kenya)A;A 3%
  • TuscanA;A 5%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs11649743 identified as one of three HNF1B gene SNPs associated with decreased risk for prostate cancer in two large prospective studies prostate cancer rs4430796 and rs11649743 in multiple populations, with P = 1.7 x 10(-9)

Source and license

Adapted from rs11649743 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.