rs1165205

A SNP in the SLC17A3 gene on chromosome 6. Its most notable genotype is T;T: 0.85x decreased gout risk

Gene
SLC17A3
Location
Chr 625,870,314 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
28%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGood0.85x decreased gout riskMinor · 1.510% of people
  2. A;TGood0.85x decreased gout riskMinor · 1.430% of people
  3. A;ABadnormalMinor · 1.060% of people

SNPedia records rs1165205 on the minus strand: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 10% A;T 30% A;A 60%
  • European ancestry (Utah)T;T 22% A;T 52% A;A 26%
  • Han Chinese (Beijing)T;T 2% A;T 30% A;A 68%
  • Japanese (Tokyo)T;T 4% A;T 28% A;A 68%
  • Yoruba (Nigeria)T;T 0% A;T 6% A;A 94%
  • African ancestry (Southwest US)T;T 0% A;T 25% A;A 75%
  • Chinese (Denver)T;T 4% A;T 30% A;A 66%
  • Gujarati IndianT;T 27% A;T 54% A;A 20%
  • Luhya (Kenya)T;T 0% A;T 2% A;A 98%
  • Mexican ancestry (Los Angeles)T;T 16% A;T 43% A;A 41%
  • Maasai (Kenya)T;T <1% A;T 13% A;A 87%
  • TuscanT;T 38% A;T 47% A;A 15%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1165205 is a SNP in the SLC17A3 gene on ch 6. A large study totaling 7,699 participants in the Framingham cohort and 4,148 participants in the Rotterdam cohort was conducted, with genome-wide significant SNPs then replicated in 11,000+ Caucasian and ~4,000 African-American individuals who took part in the study of Atherosclerosis Risk in Communities (ARIC). This study calculated an odds ratio of 0.85 for rs1165205, (CI: 0.77-0.94, p = 0.002). A genetic score comprised of this SNP plus 2 others may stratify risk for gout. See also: 23andMe blog gout *rs2231142(T) 1.7x *rs16890979(C) 1.7x *rs1165205(A) 1.2x

Source and license

Adapted from rs1165205 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.