rs116843064
A SNP in the ANGPTL4 gene on chromosome 19. Its most notable genotype is G;G: common on affy axiom data
- Gene
- ANGPTL4
- Location
- Chr 198,364,439 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- AncestryDNA
- Minor allele frequency
- 2%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Notes
From SNPedia
Notes
rs116843064, also known as c.118G>A, p.Glu40Lys and E40K, represents a low frequency (~3%) variant in the ANGPTL4 gene on chromosome 19. Studies about the effect of the E40K minor allele, rs116843064(A), are mixed: * In 2007, it was reported to be associated with lower plasma triglyceride levels and higher high density lipoprotein (HDL) * In 2009, though reported to be associated with low (therefore "good") triglyceride levels, it appeared actually increase risk of coronary heart disease by ~50% * In 2016, it was reported to be associated with lslightly lower risk for coronary artery disease (odds ratio 0.86)
Source and license
Adapted from rs116843064 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.