rs116855232

A SNP in the NUDT15 gene on chromosome 13. Its most notable genotype is C;T: Much higher (>10x) risk for leukopenia if treated with thiopurines

Gene
NUDT15
Location
Chr 1348,045,719 (GRCh38)
Highest magnitude
4.0Very important
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in clinvarTypical · 0.0
  2. C;TMost notableBadMuch higher (>10x) risk for leukopenia if treated with thiopurinesVery important · 4.0

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

c.415C>T, p.Arg139Cys, R139C; associated with poor response to azathioprine and mercaptopurine The rs116855232(T) allele was strongly associated with thiopurine-induced early leukopenia (OR 35.6, p = 4.88 × 10e-94), based on a study of ~1000 Koreans, where this variant demonstrated sensitivity and specificity of 89.4% and 93.2%, respectively, for thiopurine-induced early leukopenia. This SNP was also strongly associated with thiopurine-induced leukopenia in subjects with inflammatory bowel disease of European descent (OR 9.5, p = 4.64 × 10e-4).

C;T

see rs116855232

Source and license

Adapted from rs116855232 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.