rs11746443
A SNP in the RGS14 gene on chromosome 5. Its most notable genotype is A;A: 1.19x risk of kidney stone in Japanese
- Gene
- RGS14
- Location
- Chr 5177,371,305 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 19%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBad1.19x risk of kidney stone in Japanese
- A;GBad1.19x risk of kidney stone in Japanese
- G;GGoodnormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 4% A;G 25% G;G 71%
- European ancestry (Utah)A;A 11% A;G 38% G;G 51%
- Han Chinese (Beijing)A;A 4% A;G 29% G;G 68%
- Japanese (Tokyo)A;A 3% A;G 34% G;G 64%
- Yoruba (Nigeria)A;A <1% A;G 10% G;G 90%
- African ancestry (Southwest US)A;A 2% A;G 16% G;G 83%
- Chinese (Denver)A;A 3% A;G 23% G;G 74%
- Gujarati IndianA;A 4% A;G 40% G;G 56%
- Luhya (Kenya)A;A 0% A;G 5% G;G 96%
- Mexican ancestry (Los Angeles)A;A 9% A;G 33% G;G 59%
- Maasai (Kenya)A;A 2% A;G 15% G;G 83%
- TuscanA;A 8% A;G 34% G;G 58%
Notes
From SNPedia
Show notes, about 130 words
Nephrolithiasis is a common nephrologic disorder with complex etiology. To identify the genetic factor(s) for nephrolithiasis, we conducted a three-stage genome-wide association study (GWAS) using a total of 5,892 nephrolithiasis cases and 17,809 controls of Japanese origin. Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10−12, odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10−14, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10−9, OR = 1.14). Subsequent analyses in 21,842 Japanese subjects revealed the association of SNP rs11746443 with the reduction of estimated glomerular filtration rate (eGFR) (P = 6.54×10−8), suggesting a crucial role for this variation in renal function.
Source and license
Adapted from rs11746443 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.