rs117913124
A SNP in the CYP2R1 gene on chromosome 11. Its most notable genotype is A;A: At least 2x higher risk for vitamin D insufficiency; also somewhat higher risk for MS
- Gene
- CYP2R1
- Location
- Chr 1114,879,385 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadAt least 2x higher risk for vitamin D insufficiency; also somewhat higher risk for MS
- A;GBad~2x higher risk for vitamin D insufficiency; also 1.4x higher risk for MS
- G;GGoodcommon/normal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs117913124 represents a synonymous variant (p.Aps120Asp) in the CYP2R1 gene on chromosome 11. Sequencing, imputation and meta-analysis led to the conclusion that the rs117913124(A) minor allele leads to ~2x the risk of Vitamin D insufficiency, defined as 25OHD levels < 50nmol/L (odds ratio 2.2, CI:1.8-2.8, p = 1.2x10e12). Individuals carrying a rs117913124(A) allele also had somewhat higher odds of developing multiple sclerosis (OR 1.4, CI: 1.19-1.64, p = 2.63x10e-5).
A;A
see text at rs117913124
A;G
see text at rs117913124
Source and license
Adapted from rs117913124 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.