rs11887534

A SNP in the ABCG8 gene on chromosome 2. Its most notable genotype is C;C: 7x increased risk for gallstones

Gene
ABCG8
Location
Chr 243,839,108 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
6%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad7x increased risk for gallstonesImportant · 3.0<1% of people
  2. C;GBad2x increased risk for gallstonesWorth knowing · 2.16% of people
  3. G;GGoodnormal risk for gallstonesTypical · 0.093% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C <1% C;G 6% G;G 93%
  • European ancestry (Utah)C;C 2% C;G 13% G;G 86%
  • Han Chinese (Beijing)C;C 0% C;G 4% G;G 96%
  • Japanese (Tokyo)C;C 0% C;G 2% G;G 98%
  • Yoruba (Nigeria)C;C 2% C;G 5% G;G 94%

Conditions, medicines and genes

Other ABCG8 SNPs

All ABCG8 SNPs

Notes

From SNPedia

Notes

rs11887534, a SNP in the hepatic cholesterol transporter ABCG8 gene, has been implicated in gallstone disease, a process known formally as cholelithiasis. The common allele, rs11887534(G), encodes the aspartic acid (D), while the minor (C) allele encodes histidine (H). In a study of ~1,000 German patients, the overall odds ratio associated with rs11887534(C) carriers was 2.2 (CI: 1.8-2.6, p=1.4x10 -14 ), and for (C;C) homozygotes, 7x. Up to 10% of the population attributable risk for gallstones may be accounted for by this SNP.

Source and license

Adapted from rs11887534 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.