rs1194865614
A SNP. Its most notable genotype is -;TA: Reported to increase lifespan and reduce diabetes risk
- Gene
- None listed
- Highest magnitude
- 7.7Very important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Goodcommon/normal
- -;TAMost notableGoodReported to increase lifespan and reduce diabetes risk
- TA;TABadBleeding disorders and related complications possible
On SNPedia: (-;-), (-;TA), (TA;TA). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 140 words
Located on chromosome 7, and more commonly known in the literature as the c.699_700dupTA mutation, this rare variant represents a loss-of-function mutation in the SERPINE1 gene encoding the protein plasminogen activator inhibitor 1 (PAI-1). Other names include c.697_698TA and c.697_698dupTA. An individual inheriting two such mutations will lack PAI-1, and if untreated, complete plasminogen activator inhibitor 1 (PAI-1) deficiency is characterized by mild to moderate bleeding and related medical issues.GeneReviews In a Berne Amish cohort, heterozygotes for this mutation, who may less PAI-1 but not none, appear to live longer (by ~10 years). These individuals appear to have lower fasting insulin levels, and lower prevalence of diabetes mellitus as well, compared to the common homozygotes.
-;TA
see text and links via main rs-page
TA;TA
see text and links via main rs-page
Source and license
Adapted from rs1194865614 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.