rs12007229

A SNP on chromosome X. Its most notable genotype is C;C: Increased risk for incident vascular dementia

Gene
None listed
Location
Chr X67,528,513 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
10%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadIncreased risk for incident vascular dementiaTypical · 0.082% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 82%
  • European ancestry (Utah)C;C 82%
  • Han Chinese (Beijing)C;C 100%
  • Japanese (Tokyo)C;C 100%
  • Yoruba (Nigeria)C;C 65%
  • African ancestry (Southwest US)C;C 80%
  • Gujarati IndianC;C 94%
  • Luhya (Kenya)C;C 57%
  • Mexican ancestry (Los Angeles)C;C 93%
  • Maasai (Kenya)C;C 66%
  • TuscanC;C 86%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs12007229 is located on the X chromosome near the androgen receptor gene. In a genome-wide association study of 5700 dementia-free individuals, 67 patients developed incident vascular dementia over a mean follow-up time of 9.3±3.2 years. The rs12007229(A) allele was associated with this development (odds ratio 3.7, CI: 2.3-5.8, p = 1.3×10e-8). The association was further confirmed in 2 independent populations (probability value of combined replication samples=0.024).

C;C

Increased risk for incident vascular dementia

Source and license

Adapted from rs12007229 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.