rs12037606

A SNP on chromosome 1. Its most notable genotype is A;A: 1.52x risk of developing Crohn's disease

Gene
None listed
Location
Chr 1172,929,262 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.52x risk of developing Crohn's diseaseWorth knowing · 2.053% of people
  2. A;GBad1.22x risk of developing Crohn's diseaseMinor · 1.534% of people
  3. C;CNot ratedNo summary available.Typical · 0.00% of people
  4. G;GGoodNormal risk of developing Crohn's diseaseMinor · 1.013% of people

On SNPedia: (A;A), (A;G), (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 53% A;G 34% C;C 0% G;G 13%
  • European ancestry (Utah)A;A 13% A;G 47% C;C 0% G;G 40%
  • Han Chinese (Beijing)A;A 84% A;G 15% C;C 0% G;G <1%
  • Japanese (Tokyo)A;A 97% A;G 4% C;C 0% G;G 0%
  • Yoruba (Nigeria)A;A 44% A;G 45% C;C 0% G;G 12%
  • African ancestry (Southwest US)A;A 52% A;G 30% C;C 0% G;G 18%
  • Chinese (Denver)A;A 87% A;G 13% C;C 0% G;G 0%
  • Gujarati IndianA;A 50% A;G 38% C;C 0% G;G 13%
  • Luhya (Kenya)A;A 54% A;G 41% C;C 0% G;G 6%
  • Mexican ancestry (Los Angeles)A;A 41% A;G 52% C;C 0% G;G 7%
  • Maasai (Kenya)A;A 46% A;G 44% C;C 0% G;G 10%
  • TuscanA;A 18% A;G 50% C;C 0% G;G 32%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs12037606 has been reported in a large study to be associated with Crohn's disease. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.22 (CI 1.07-1.40), and for homozygotes, 1.52 (CI 1.28-1.82).

Source and license

Adapted from rs12037606 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.