rs12044852

A SNP in the CD58 gene on chromosome 1. Its most notable genotype is A;A: common

Gene
CD58
Location
Chr 1116,545,157 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
24%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommonTypical · 0.011% of people
  2. A;CBad1.24x riskTypical · 0.027% of people
  3. C;CBad>1.24x riskTypical · 0.062% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 11% A;C 27% C;C 62%
  • European ancestry (Utah)A;A 3% A;C 20% C;C 77%
  • Han Chinese (Beijing)A;A 30% A;C 46% C;C 24%
  • Japanese (Tokyo)A;A 43% A;C 40% C;C 18%
  • Yoruba (Nigeria)A;A 0% A;C 12% C;C 88%
  • African ancestry (Southwest US)A;A 2% A;C 9% C;C 90%
  • Chinese (Denver)A;A 28% A;C 48% C;C 24%
  • Gujarati IndianA;A 7% A;C 40% C;C 54%
  • Luhya (Kenya)A;A 0% A;C 10% C;C 90%
  • Mexican ancestry (Los Angeles)A;A 7% A;C 31% C;C 62%
  • Maasai (Kenya)A;A 0% A;C 17% C;C 83%
  • TuscanA;A 2% A;C 20% C;C 78%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs12044852 has been reported in a large study to be associated with multiple sclerosis. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with this allele is 1.24 (CI 1.12-1.37).

Source and license

Adapted from rs12044852 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.