rs12143842

A SNP on chromosome 1. Its most notable genotype is C;C: normal

Gene
None listed
Location
Chr 1162,064,100 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
24%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.058% of people
  2. C;TNot rated4.4ms QT interval duration increase on averageTypical · 0.035% of people
  3. T;TNot rated8.8ms QT interval duration increase on averageTypical · 0.07% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 58% C;T 35% T;T 7%
  • European ancestry (Utah)C;C 64% C;T 34% T;T 2%
  • Han Chinese (Beijing)C;C 43% C;T 50% T;T 7%
  • Japanese (Tokyo)C;C 42% C;T 44% T;T 14%
  • Yoruba (Nigeria)C;C 71% C;T 27% T;T 2%
  • African ancestry (Southwest US)C;C 65% C;T 33% T;T 2%
  • Chinese (Denver)C;C 44% C;T 49% T;T 7%
  • Gujarati IndianC;C 35% C;T 44% T;T 22%
  • Luhya (Kenya)C;C 85% C;T 14% T;T 2%
  • Mexican ancestry (Los Angeles)C;C 60% C;T 33% T;T 7%
  • Maasai (Kenya)C;C 80% C;T 19% T;T 1%
  • TuscanC;C 53% C;T 39% T;T 8%

Notes

From SNPedia

Notes

rs12143842 is a SNP within 100kb of the NOS1AP gene. A study of participants in the Rotterdam Study, a population-based, prospective cohort study of individuals >/=55 years of age, concluded that each rs12143842(T) allele was associated with a QT-interval duration increase of 4.4-ms (p =4.4x10e-28). This SNP is the most strongly associated with QT interval of all known to date (at the time of publication). ===Publications===

Source and license

Adapted from rs12143842 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.