rs12184413

A SNP in the MMP7 gene on chromosome 11. Its most notable genotype is C;C: normal

Gene
MMP7
Location
Chr 11102,518,857 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
14%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.072% of people
  2. C;TNot ratednormalTypical · 0.026% of people
  3. T;TNot rated0.7x decreased risk for breast cancerTypical · 0.02% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 72% C;T 26% T;T 2%
  • European ancestry (Utah)C;C 81% C;T 17% T;T 2%
  • Han Chinese (Beijing)C;C 46% C;T 46% T;T 7%
  • Japanese (Tokyo)C;C 61% C;T 39% T;T 0%
  • Yoruba (Nigeria)C;C 100% C;T 0% T;T 0%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs12184413(T;T) was associated with reduced risk for breast cancer, with an odds ratio of 0.7 (CI: 0.6-0.9), based on a study ultimately totaling over 3,000 cases (and an equal number of controls). Genetic polymorphisms in the MMP-7 gene and breast cancer survival. No association between matrix metalloproteinase (MMP)-1, MMP-3, and MMP-7 SNPs and endometrial cancer risk.

Source and license

Adapted from rs12184413 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.