rs121909377(A;C)

Miscall likely if from 23andMe data; If not, familial hypertrophic cardiomyopathy 4

Magnitude
4.0Very important
Repute
Bad
On SNPedia
rs121909377(G;T)Minus strand
Gene
MYBPC3

Other genotypes of rs121909377

  1. C;CGoodcommon in clinvarTypical · 0.0

All about rs121909377

Notes

From SNPedia

1999 and 2015 publications report that the minor allele is a dominant mutation leading to familial hypertrophic cardiomyopathy 4. However, SNPedia has observed that 23andMe data may miscall this mutation, and their customers should check their i5005171 genotype, which independently checks this mutation. If i5005171 is CC, it's the common/normal genotype, but if i5005171 is AC, it confirms carrying the rare HCM mutation originally reported in 1999.

Source and license

Adapted from rs121909377(G;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.