rs121909667

A SNP in the FUS gene on chromosome 16. Its most notable genotype is G;G: Causing ALS AMYOTROPHIC LATERAL SCLEROSIS

Gene
FUS
Location
Chr 1631,191,408 (GRCh38)
Highest magnitude
6.0Very important
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in clinvarTypical · 0.0
  2. G;GMost notableBadCausing ALS AMYOTROPHIC LATERAL SCLEROSISVery important · 6.0

On SNPedia: (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other FUS SNPs

All FUS SNPs

Notes

From SNPedia

Notes

G;G

AMYOTROPHIC LATERAL SCLEROSIS 6 In 4 affected members of a consanguineous family with amyotrophic lateral sclerosis-6 (ALS6; 608030), Kwiatkowski et al. (2009) identified a homozygous 1551C-G transversion in exon 15 of the FUS gene, resulting in a his517-to-gln (H517Q) substitution. The family originated from Cape Verde, a small island off the western coast of Africa. Three asymptomatic family members were also homozygous for the mutation, but all were younger than the mean age at disease onset of 45 years. The mutation was not detected in 1,446 control DNA samples from North America; 1 heterozygote was observed in 132 chromosomes from Cape Verde.

Source and license

Adapted from rs121909667 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.