rs121912617

rs121912617, also known as Pro384Arg or P384R, is a SNP in the basic helix-loop-helix family, member e41 BHLHE41 gene. Note that some publications and OMIM refer to this as Pro385 (rather than 384). Individuals heterozygous for rs121912617 are known as Familial Natural Short Sleepers (FNSS), and they sleep 6–6.5 hours per night (∼2 hours less than controls) on average, without reporting any sense of sleep deprivation. This is classified as a sleep disorder, although it does not appear to have any known negative medical consequence. The correlation between P384R and FNSS was first reported in 2009. In 2014, an independent group studying a (relatively small) group of people also saw the correlation between P384 and FNSS, while also finding another similiar variant in the BHLHE41 gene, Y362H (c.1084C>T; also known as Tyr362His). The Y362H variant does not have a dbSNP SNP designation at this time. Research published in 2018 suggests that in human short sleepers, this variant weakens the DEC2 protein's ability to suppress the MyoD1 protein, which in turn leads to more orexin production, causing short sleepers to stay awake longer.;news

C;G

Individuals with this genotype are reported to need about 2 hours less sleep than most people.

C;C

You have a rare genotype which suggests you need less sleep than most people. The research concludes that 1 copy of the rare allele allows you to function on 6 hours sleep, instead of 8. You have 2 copies of the rare allele. info@snpedia.com would like to hear from you, to know if having 2 copies further reduces the necessary time. Note that this is an ambiguous flip; before contacting us, please make sure that your Promethease report shows rs121912617(G;G). If you are not looking at your Promethease report, and instead you are manually looking at your raw data, it (your raw data) will show (C;C) if you have this rare genotype since the raw data from most companies is based on the forward strand whereas this SNP is based in dbSNP and in SNPedia on the reverse strand. If you see (G;G) in your raw data you do not have this rare genotype; you have the very common genotype.