rs121913355

A SNP in the BRAF gene on chromosome 7. Its most notable genotype is C;T: Rasopathy; Cardio-facio-cutaneous syndrome

Gene
BRAF
Location
Chr 7140,781,602 (GRCh38)
Highest magnitude
7.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;TMost notableBadRasopathy; Cardio-facio-cutaneous syndromeVery important · 7.0
  2. C;CGoodcommon in clinvarTypical · 0.0

SNPedia records rs121913355 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other BRAF SNPs

All BRAF SNPs

Notes

From SNPedia

Notes

rs121913355 represents several variants in the BRAF gene on chromosome 7. As represented in dbSNP on the minus strand, which is also the cDNA strand, the reference allele is rs121913355(G), also known as c.1406G. The variant known as c.1406G>A (p.Gly469Glu) is annotated by an expert panel in ClinVar as associated with a rasopathy; whereas c.1406G>C and c.1406G>T are both annotated in ClinVar as somatic mutations seen in certain cancers. 23andMe name for c.1406G>A: i6008195

C;T

See links via main rs-page

Source and license

Adapted from rs121913355 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.