rs12229892
A SNP in the PTPN11 gene on chromosome 12. Its most notable genotype is G;G: common in complete genomics
- Gene
- PTPN11
- Location
- Chr 12112,485,589 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- AncestryDNA
- Minor allele frequency
- 13%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 9 HapMap populations.
- AverageG;G 73%
- European ancestry (Utah)G;G 100%
- Han Chinese (Beijing)G;G 29%
- Japanese (Tokyo)G;G 22%
- Yoruba (Nigeria)G;G 100%
- African ancestry (Southwest US)G;G 98%
- Chinese (Denver)G;G 25%
- Gujarati IndianG;G 99%
- Luhya (Kenya)G;G 98%
- Mexican ancestry (Los Angeles)G;G 90%
Related
Other PTPN11 SNPs
- rs28933386A;GNoonan syndromeVery important
- rs121918457C;TNoonan syndromeVery important
- rs121918459A;GNoonan syndromeVery important
- rs121918470A;CNoonan syndromeVery important
- rs376607329A;GNoonan syndromeVery important
- rs397507503C;TNoonan syndromeVery important
- rs397507520C;GNoonan syndromeVery important
- rs397507525C;TNoonan syndromeVery important
Notes
From SNPedia
Notes
Associations between a PTPN11 polymorphism and gastric atrophy--opposite in Uzbekistan to that in Japan. Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese.
Source and license
Adapted from rs12229892 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.