rs1223271

A SNP in the TASP1 gene on chromosome 20. Its most notable genotype is A;A: Increased risk of developing Parkinson's Disease

Gene
TASP1
Location
Chr 2013,316,265 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadIncreased risk of developing Parkinson's DiseaseWorth knowing · 2.07% of people
  2. A;GBadSlightly increased risk of developing Parkinson's DiseaseMinor · 1.524% of people
  3. G;GGoodNormal risk of developing Parkinson's DiseaseMinor · 1.069% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 7% A;G 24% G;G 69%
  • European ancestry (Utah)A;A 3% A;G 17% G;G 80%
  • Han Chinese (Beijing)A;A 21% A;G 49% G;G 31%
  • Japanese (Tokyo)A;A 12% A;G 49% G;G 39%
  • Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
  • African ancestry (Southwest US)A;A 0% A;G 5% G;G 95%
  • Chinese (Denver)A;A 19% A;G 41% G;G 39%
  • Gujarati IndianA;A 8% A;G 42% G;G 51%
  • Luhya (Kenya)A;A 0% A;G 3% G;G 97%
  • Mexican ancestry (Los Angeles)A;A 9% A;G 28% G;G 64%
  • Maasai (Kenya)A;A 0% A;G 7% G;G 93%
  • TuscanA;A 2% A;G 29% G;G 69%

Source and license

Adapted from rs1223271 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.