rs12329760
A SNP in the TMPRSS2 gene on chromosome 21. Its most notable genotype is C;C: common/normal
- Gene
- TMPRSS2
- Location
- Chr 2141,480,570 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 29%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 53%
- European ancestry (Utah)C;C 57%
- Han Chinese (Beijing)C;C 38%
- Japanese (Tokyo)C;C 40%
- Yoruba (Nigeria)C;C 56%
- African ancestry (Southwest US)C;C 54%
- Chinese (Denver)C;C 37%
- Gujarati IndianC;C 73%
- Luhya (Kenya)C;C 52%
- Mexican ancestry (Los Angeles)C;C 69%
- Maasai (Kenya)C;C 42%
- TuscanC;C 67%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 170 words
news Cases with the TMPRSS2-ERG fusion did not exhibit reduced prostate cancer survival (HR=0.92, 95% CI=0.22-3.93), nor was there a significant difference in cause-specific survival when stratifying by translocation or deletion (HR=0.84, 95% CI=0.23-3.12) or by the number of retained fusion copies (HR=1.22, 95% CI=0.45-3.34). However, evidence for reduced prostate cancer-specific survival was apparent in those cases whose tumor had multiple copies of the fusion. The variant T allele of the TMPRSS2 SNP, rs12329760, was positively associated with TMPRSS2-ERG fusion by translocation (p=0.05) and with multiple copies of the gene fusion (p=0.03). Conclusion: If replicated, the results presented here may provide insight into the mechanism by which the TMPRSS2-ERG gene fusion arises and also contribute to diagnostic evaluations for determining the subset of men who will go on to develop metastatic prostate cancer. prostate cancer T allele appears to have lower survival, and higher recurrence.
Source and license
Adapted from rs12329760 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.