rs12402521

A SNP in the PDC gene on chromosome 1. Its most notable genotype is G;G: 12–15 mmHg higher blood pressure when under stress

Gene
PDC
Location
Chr 1186,453,389 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
Not on consumer chips
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot rated12–15 mmHg higher blood pressure when under stressWorth knowing · 2.037% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 37%
  • European ancestry (Utah)G;G 60%
  • Han Chinese (Beijing)G;G 29%
  • Japanese (Tokyo)G;G 30%
  • Yoruba (Nigeria)G;G 31%

Notes

From SNPedia

Notes

Candidate gene–based association studies in 2 different human populations revealed several SNPs in the PDC gene to be associated with stress-dependent hypertension. Individuals homozygous for the G allele of an intronic PDC SNP (rs12402521) had 12–15 mmHg higher blood pressure than those carrying the A allele.JCI 2009

Source and license

Adapted from rs12402521 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.