rs12431733

A SNP in the LOC105370503 gene on chromosome 14. Its most notable genotype is T;T: Increased risk of developing Parkinson's Disease

Gene
LOC105370503
Location
Chr 1453,824,112 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
37%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNormal risk of developing Parkinson's DiseaseMinor · 1.013% of people
  2. C;TBadSlightly increased risk of developing Parkinson's DiseaseMinor · 1.542% of people
  3. T;TMost notableBadIncreased risk of developing Parkinson's DiseaseWorth knowing · 2.045% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 13% C;T 42% T;T 45%
  • European ancestry (Utah)C;C 22% C;T 47% T;T 31%
  • Han Chinese (Beijing)C;C 7% C;T 33% T;T 61%
  • Japanese (Tokyo)C;C 4% C;T 25% T;T 71%
  • Yoruba (Nigeria)C;C 18% C;T 41% T;T 42%
  • African ancestry (Southwest US)C;C 16% C;T 54% T;T 30%
  • Chinese (Denver)C;C 4% C;T 33% T;T 63%
  • Gujarati IndianC;C 9% C;T 46% T;T 45%
  • Luhya (Kenya)C;C 9% C;T 51% T;T 40%
  • Mexican ancestry (Los Angeles)C;C 10% C;T 45% T;T 45%
  • Maasai (Kenya)C;C 16% C;T 49% T;T 36%
  • TuscanC;C 31% C;T 39% T;T 29%

Source and license

Adapted from rs12431733 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.