rs12487066

A SNP in the LOC105374027 gene on chromosome 3. Its most notable genotype is C;C: >1.09x increased risk for multiple sclerosis

Gene
LOC105374027
Location
Chr 3106,193,283 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot rated>1.09x increased risk for multiple sclerosisTypical · 0.08% of people
  2. C;TNot rated1.09x increased risk for multiple sclerosisTypical · 0.042% of people
  3. T;TNot ratedcommonTypical · 0.050% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 8% C;T 42% T;T 50%
  • European ancestry (Utah)C;C 10% C;T 45% T;T 45%
  • Han Chinese (Beijing)C;C 5% C;T 37% T;T 58%
  • Japanese (Tokyo)C;C 8% C;T 43% T;T 49%
  • Yoruba (Nigeria)C;C 6% C;T 32% T;T 62%
  • African ancestry (Southwest US)C;C 5% C;T 42% T;T 53%
  • Chinese (Denver)C;C 6% C;T 32% T;T 62%
  • Gujarati IndianC;C 15% C;T 51% T;T 35%
  • Luhya (Kenya)C;C 15% C;T 41% T;T 45%
  • Mexican ancestry (Los Angeles)C;C 3% C;T 57% T;T 40%
  • Maasai (Kenya)C;C 12% C;T 48% T;T 40%
  • TuscanC;C 4% C;T 31% T;T 65%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs12487066 has been reported in a large study to be associated with multiple sclerosis. The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with this allele is 1.09 (CI 1.03-1.16).

Source and license

Adapted from rs12487066 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.