rs12520016

A SNP in the LOC102724943 gene on chromosome 5. Its most notable genotype is G;G: G allele associated with intermediate eye color and decreased risk of melanoma

Gene
LOC102724943
Location
Chr 56,767,199 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
4%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedG allele associated with intermediate eye color and decreased risk of melanomaTypical · 0.0<1% of people
  2. G;TNot ratedG allele associated with intermediate eye color and decreased risk of melanomaTypical · 0.09% of people
  3. T;TGoodmost common/normalTypical · 0.091% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G <1% G;T 9% T;T 91%
  • European ancestry (Utah)G;G <1% G;T 10% T;T 89%
  • Han Chinese (Beijing)G;G 0% G;T <1% T;T 99%
  • Japanese (Tokyo)G;G 0% G;T 0% T;T 100%
  • Yoruba (Nigeria)G;G <1% G;T 24% T;T 76%
  • African ancestry (Southwest US)G;G 0% G;T 16% T;T 84%
  • Chinese (Denver)G;G 0% G;T <1% T;T 99%
  • Gujarati IndianG;G 0% G;T 3% T;T 97%
  • Luhya (Kenya)G;G 0% G;T 14% T;T 86%
  • Mexican ancestry (Los Angeles)G;G 0% G;T 2% T;T 98%
  • Maasai (Kenya)G;G <1% G;T 25% T;T 75%
  • TuscanG;G 0% G;T 6% T;T 94%

Notes

From SNPedia

Notes

The 'G' allele is associated with a more "intermediate" (Green) eye color and lower risk of melanoma, compared to the 'T' allele.

G;G

G allele associated with intermediate eye color and decreased risk of melanoma

G;T

G allele associated with intermediate eye color and decreased risk of melanoma

Source and license

Adapted from rs12520016 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.