rs12536657

A SNP in the HGF gene on chromosome 7. Its most notable genotype is A;A: hypermetropia risk - longsightedness

Gene
HGF
Location
Chr 781,720,892 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe
Minor allele frequency
13%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadhypermetropia risk - longsightednessWorth knowing · 2.51% of people
  2. G;GGoodNo summary available.Typical · 0.080% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 1% G;G 80%
  • European ancestry (Utah)A;A <1% G;G 63%
  • Han Chinese (Beijing)A;A 2% G;G 83%
  • Japanese (Tokyo)A;A <1% G;G 83%
  • Yoruba (Nigeria)A;A 0% G;G 99%
  • African ancestry (Southwest US)A;A 0% G;G 86%
  • Chinese (Denver)A;A 8% G;G 65%
  • Gujarati IndianA;A 1% G;G 73%
  • Luhya (Kenya)A;A 0% G;G 95%
  • Mexican ancestry (Los Angeles)A;A 2% G;G 72%
  • Maasai (Kenya)A;A 0% G;G 96%
  • TuscanA;A 2% G;G 65%

Other HGF SNPs

All HGF SNPs

Notes

From SNPedia

Notes

G;G

common among pgp10

Source and license

Adapted from rs12536657 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.