rs12587742
A SNP in the DCAF4 gene on chromosome 14. Its most notable genotype is A;A: Slightly increased (1.18x) risk for lung cancer
- Gene
- DCAF4
- Location
- Chr 1472,926,683 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadSlightly increased (1.18x) risk for lung cancer
- A;GBadSlightly increased (1.09x) risk for lung cancer
- G;GGoodNormal risk for lung cancer
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 8% A;G 29% G;G 63%
- European ancestry (Utah)A;A 6% A;G 22% G;G 73%
- Han Chinese (Beijing)A;A 8% A;G 50% G;G 42%
- Japanese (Tokyo)A;A 18% A;G 40% G;G 43%
- Yoruba (Nigeria)A;A 0% A;G 5% G;G 95%
Notes
From SNPedia
Notes
A;A
Data of six published genome-wide association studies (GWASs) of 12,160 cases and 16,838 cases of European ancestry suggests an association between this SNP in the DCAF4 gene lung cancer.
A;G
Data of six published genome-wide association studies (GWASs) of 12,160 cases and 16,838 cases of European ancestry suggests an association between this SNP in the DCAF4 gene lung cancer.
Source and license
Adapted from rs12587742 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.